Genetic architecture of memory and executive functioning in Alzheimer's
disease 
   Lead Investigator:    Elizabeth Sanders
   Institution      :    UW
   E-Mail           :    pcrane@uw.edu
   Proposal ID      :    517


   Publications:


1  Crane P
   Genetic architecture of memory and executive functioning in Alzheimer's disease
   41883   Grant  NIH   R01 AG042437   , 

   FUNDED





   Proposal Description:
   The study team will use modern psychometric methods to co-calibrate cognitive data across all of the contributing studies to develop scores on the same metric for memory and executive functioning. We will use these scores to determine a continuous dysexecutive spectrum phenotype, defined as the difference between memory and executive functioning. This leads to at one end of the spectrum people whose memory is impressively bad but whose exective functioning is relatively intact, while at the other end people whose executive functioning is even more impaired than their memory. We will then use this derived phenotype in genetic analyses, including GWAS, gene-wide, and pathway approaches, and for people with sequence data we will also evaluate sequence data and this phenotype.